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VUMC-led study finds Moderna COVID vaccine safe and effective for children

VUMC-led study finds Moderna COVID vaccine safe and effective for children

Moderna’s COVID-19 vaccine is safe and generates robust immune responses in children ages 6 to 11 years, a national clinical trial co-led by Vanderbilt University Medical Center vaccine expert C. Buddy Creech, MD, MPH, has found.  

Resistance to COVID-19 drug detected in lab study

The virus that causes COVID-19 can develop partial resistance to the antiviral drug remdesivir during infection of cultured cells in the laboratory by more than one mechanism. The results of the laboratory study led by researchers at Vanderbilt University Medical Center and published April 28 in the journal Science Translational Medicine support the importance of … Continued

Microbiome reflects COVID-19 severity

SARS-CoV-2 infection notoriously impairs respiratory function. Given that the microbiome, or community of microorganisms inhabiting the upper respiratory tract (URT), is involved in regulating respiratory health and immune response, a timely study by Suman Das, Ph.D., and colleagues assessed whether the URT microbiome reflects COVID-19 severity.

Pandemic leads to broader use of monoclonal antibodies

Most at risk: the millions of Americans who are still unvaccinated or not fully vaccinated, and those whose immune systems are compromised or have been suppressed and do not respond to vaccinations. These include patients being treated for cancer or who have received organ transplants. That is why antiviral drugs and coronavirus-fighting monoclonal antibodies, including … Continued

Study shows young, healthy adults died from COVID-19 due to ECMO shortage

Nearly 90% of COVID-19 patients who qualified for, but did not receive, ECMO (extracorporeal membrane oxygenation) due to a shortage of resources during the height of the pandemic died in the hospital, despite being young with few other health issues, according to a study published in the American Journal of Respiratory and Critical Care Medicine.

Study shows life-saving benefit of baricitinib for ventilated COVID patients

Critically ill COVID-19 patients on a mechanical ventilator or extracorporeal membrane oxygenation (ECMO) lived more often when randomized to receive baricitinib. Doctors call this drug ‘bari,’ and receiving the pill once a day for up to 14 days yielded one of the largest a survival advantages seen yet in the COVID pandemic, according to a … Continued

Omicron evades some but not all monoclonal antibodies: study

The laboratory study, led by researchers at Washington University School of Medicine in St. Louis, Missouri, tested five antibody combinations including precursor antibodies discovered at Vanderbilt University Medical Center that subsequently were optimized by AstraZeneca and which were authorized for emergency use in patients last month.

Study of fully vaccinated patients with cancer who had breakthrough COVID-19 shows 13% mortality rate

The first study to evaluate the clinical characteristics and outcomes of fully vaccinated patients with cancer who had breakthrough COVID-19 infections indicates they remained at high risk for hospitalization and death.

Antibodies discovered at Vanderbilt for prevention of COVID-19 granted FDA emergency use authorization

On Wednesday, the U.S. Food and Drug Administration granted emergency use authorization (EUA) to the global biopharmaceutical company AstraZeneca for a long-acting antibody combination which protects against COVID-19, discovered last year at Vanderbilt University Medical Center (VUMC). A number of medical conditions result in immune compromise, from treatments for many cancers to organ transplantation.

Antibodies discovered at Vanderbilt for prevention of COVID-19 granted FDA emergency use authorization

On Wednesday, the U.S. Food and Drug Administration granted emergency use authorization (EUA) to the global biopharmaceutical company AstraZeneca for a long-acting antibody combination which protects against COVID-19, discovered last year at Vanderbilt University Medical Center (VUMC). A number of medical conditions result in immune compromise, from treatments for many cancers to organ transplantation.